Lentiviral Infections Persist in Brain despite Effective Antiretroviral Therapy and Neuroimmune Activation-Reference-Cited by-同舟云学术

Lentiviral Infections Persist in Brain despite Effective Antiretroviral Therapy and Neuroimmune Activation

Published:2021-12-21 Issue:6 Volume:12 Page:
ISSN:2150-7511
Container-title:mBio
language:en
Short-container-title:mBio

Author:

Mohammadzadeh Nazanin¹^ORCID,Roda Weston²,Branton William G.³,Clain Julien⁴,Rabezanahary Henintsoa⁴,Zghidi-Abouzid Ouafa⁴,Gelman Benjamin B.⁵,Angel Jonathan B.⁶^ORCID,Cohen Eric A.⁷⁸^ORCID,Gill M. John⁹,Li Michael²,Estaquier Jérome⁴^ORCID,Power Christopher¹³^ORCID

Affiliation:

1. Department of Medical Microbiology and Immunology, University of Alberta, Edmonton, Alberta, Canada

2. Mathematical & Statistical Sciences, University of Alberta, Edmonton, Alberta, Canada

3. Division of Neurology, Department of Medicine, University of Alberta, Edmonton, Alberta, Canada

4. Department of Pathophysiology, CHU de Québec, Université Laval Research Center, Québec, Quebec, Canada

5. Department of Pathology, University of Texas Medical Branch, Galveston, Texas, USA

6. University of Ottawa and Ottawa Hospital Research Institute, Ottawa, Ontario, Canada

7. Institut de Recherches Cliniques de Montréal, Université de Montréal, Montreal, Quebec, Canada

8. Department of Microbiology, Infectiology, and Immunology, Université de Montréal, Montreal, Quebec, Canada

9. Department of Medicine, University of Calgary, Calgary, Alberta, Canada

Abstract

Antiretroviral therapy (ART) suppresses HIV-1 in plasma and CSF to undetectable levels. However, the impact of contemporary ART on HIV-1 brain reservoirs remains uncertain.

Funder

HHS | National Institutes of Health

Gouvernement du Canada | Canadian Institutes of Health Research

Publisher

American Society for Microbiology

Subject

Virology,Microbiology

Link

https://journals.asm.org/doi/pdf/10.1128/mBio.02784-21

Reference54 articles.

1. The Lentiviruses: Maedi/Visna, Caprine Arthritis-Encephalitis, and Equine Infectious Anemia

2. Feline immunodeficiency virus: a neurotropic lentivirus;Dow SW;J Acquir Immune Defic Syndr (1988),1990