Coronaviruses Nsp5 Antagonizes Porcine Gasdermin D-Mediated Pyroptosis by Cleaving Pore-Forming p30 Fragment

Author:

Shi Fushan1234,Lv Qian1,Wang Tingjun1,Xu Jidong1,Xu Wei14ORCID,Shi Yuhua1,Fu Xinyu1,Yang Tianming1,Yang Yang5,Zhuang Lenan1,Fang Weihuan13ORCID,Gu Jinyan12ORCID,Li Xiaoliang1236ORCID

Affiliation:

1. Department of Veterinary Medicine, College of Animal Sciences, Zhejiang University, Hangzhou, Zhejiang, China

2. MOA Key Laboratory of Animal Virology, Center for Veterinary Sciences, Zhejiang University, Hangzhou, Zhejiang, China

3. Institute of Preventive Veterinary Medicine, Zhejiang Provincial Key Laboratory of Preventive Veterinary Medicine, Zhejiang University, Hangzhou, Zhejiang, China

4. Veterinary Teaching Hospital, Center for Veterinary Sciences, Zhejiang University, Hangzhou, Zhejiang, China

5. Key Laboratory of Applied Technology on Green-Eco-Healthy Animal Husbandry of Zhejiang Province, Zhejiang Provincial Engineering Laboratory for Animal Health Inspection & Internet Technology, College of Animal Science and Technology & College of Veterinary Medicine of Zhejiang A&F University, Hangzhou, Zhejiang, China

6. Hainan Institute of Zhejiang University, Sanya, Hainan, China

Abstract

Recently, GSDMD has been reported as a key executioner for pyroptosis. This study first demonstrates the molecular mechanism of pGSDMD-mediated pyroptosis and that the pGSDMD-mediated pyroptosis protects host cells against PEDV infection.

Funder

National Natural Science Foundation of China

MOST | National Key Research and Development Program of China

Zhejiang Provincial Key R&D Program of China

Department of Education of Zhejiang Province

NSFC | NSFC-Zhejiang Joint Fund | 浙江省科学技术厅 | Natural Science Foundation of Zhejiang Province

MOE | Fundamental Research Funds for the Central Universities

Publisher

American Society for Microbiology

Subject

Virology,Microbiology

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