Intestinal Inflammation and Altered Gut Microbiota Associated with Inflammatory Bowel Disease Render Mice Susceptible to Clostridioides difficile Colonization and Infection-Reference-Cited by-同舟云学术

Intestinal Inflammation and Altered Gut Microbiota Associated with Inflammatory Bowel Disease Render Mice Susceptible to Clostridioides difficile Colonization and Infection

Published:2021-06-29 Issue:3 Volume:12 Page:
ISSN:2150-7511
Container-title:mBio
language:en
Short-container-title:mBio

Author:

Abernathy-Close Lisa¹^ORCID,Barron Madeline R.²^ORCID,George James M.³,Dieterle Michael G.⁴^ORCID,Vendrov Kimberly C.¹^ORCID,Bergin Ingrid L.⁵,Young Vincent B.¹²^ORCID

Affiliation:

1. Department of Internal Medicine/Division of Infectious Diseases, University of Michigan, Ann Arbor, Michigan, USA

2. Department of Microbiology and Immunology, University of Michigan, Ann Arbor, Michigan, USA

3. Department of Biomedical Engineering, College of Engineering, University of Michigan, Ann Arbor, Michigan, USA

4. Medical Scientist Training Program, University of Michigan, Ann Arbor, Michigan, USA

5. Unit for Laboratory Animal Medicine, University of Michigan, Ann Arbor, Michigan, USA

Abstract

The incidence of C. difficile infection (CDI) has increased significantly among patients with IBD, independently of antibiotic use, yet the relationship between IBD and increased risk for CDI remains to be understood. Our study sought to describe and utilize an antibiotic-independent mouse model to specifically explore the relationship between the IBD-associated gut and susceptibility to C. difficile colonization and CDI development.

Funder

HHS | NIH | National Center for Advancing Translational Sciences

HHS | NIH | National Institute of Allergy and Infectious Diseases

Publisher

American Society for Microbiology

Subject

Virology,Microbiology

Link

https://journals.asm.org/doi/pdf/10.1128/mBio.02733-20

Reference58 articles.

1. Rising Incidence of Intestinal Infections in Inflammatory Bowel Disease: A Nationwide Analysis

2. Incidence of Clostridium difficile Infection in Inflammatory Bowel Disease