Inositol Metabolism Regulates Capsule Structure and Virulence in the Human Pathogen Cryptococcus neoformans-Reference-Cited by-同舟云学术

Inositol Metabolism Regulates Capsule Structure and Virulence in the Human Pathogen Cryptococcus neoformans

Published:2021-12-21 Issue:6 Volume:12 Page:
ISSN:2150-7511
Container-title:mBio
language:en
Short-container-title:mBio

Author:

Wang Yina¹,Wear Maggie²,Kohli Gurkirat¹,Vij Raghav²^ORCID,Giamberardino Charles³,Shah Arpun¹,Toffaletti Dena L.³,Yu Chen-Hsin A.⁴,Perfect John R.³,Casadevall Arturo²^ORCID,Xue Chaoyang¹⁵^ORCID

Affiliation:

1. Public Health Research Institute, New Jersey Medical School, Rutgers University, Newark, New Jersey, USA

2. Department of Molecular Microbiology and Immunology, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland, USA

3. Division of Infectious Diseases, Department of Medicine, Duke University Medical Center, Durham, North Carolina, USA

4. Institute of Molecular Biology, Academia Sinica, Taipei, Taiwan

5. Department of Microbiology, Biochemistry and Molecular Genetics, New Jersey Medical School, Rutgers University, Newark, New Jersey, USA

Abstract

The human pathogen Cryptococcus neoformans is the leading cause of fungal meningitis in primarily immunocompromised populations. Understanding how this environmental organism adapts to the human host to cause deadly infection will guide our development of novel disease control strategies.

Funder

HHS | National Institutes of Health

Publisher

American Society for Microbiology

Subject

Virology,Microbiology

Link

https://journals.asm.org/doi/pdf/10.1128/mBio.02790-21

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