Ceragenins and Antimicrobial Peptides Kill Bacteria through Distinct Mechanisms

Author:

Mitchell Gabriel1ORCID,Silvis Melanie R.2,Talkington Kelsey C.1,Budzik Jonathan M.13,Dodd Claire E.1,Paluba Justin M.1,Oki Erika A.1,Trotta Kristine L.4,Licht Daniel J.1,Jimenez-Morales David56ORCID,Chou Seemay47,Savage Paul B.8,Gross Carol A.29,Marletta Michael A.11011ORCID,Cox Jeffery S.1ORCID

Affiliation:

1. Department of Molecular and Cell Biology, University of California, Berkeley, California, USA

2. Department of Microbiology and Immunology, University of California, San Francisco, California, USA

3. Department of Medicine, University of California, San Francisco, California, USA

4. Department of Biochemistry and Biophysics, University of California, San Francisco, California, USA

5. Department of Medicine, Division of Cardiovascular Medicine, Stanford University, California, USA

6. Department of Cellular and Molecular Pharmacology, University of California, San Francisco, California, USA

7. Chan Zuckerberg Biohub, San Francisco, California, USA

8. Department of Chemistry and Biochemistry, Brigham Young University, Provo, Utah, USA

9. Department of Cell and Tissue Biology, University of California, San Francisco, California, USA

10. Department of Chemistry, University of California, Berkeley, California, USA

11. California Institute for Quantitative Biosciences, University of California, Berkeley, California, USA

Abstract

The development of novel antibiotics is essential because the current arsenal of antimicrobials will soon be ineffective due to the widespread occurrence of antibiotic resistance. The development of naturally occurring cationic antimicrobial peptides (CAMPs) for therapeutics to combat antibiotic resistance has been hampered by high production costs and protease sensitivity, among other factors.

Funder

HHS | National Institutes of Health

Cystic Fibrosis Foundation

Ceragenin Research Fund (Bill Brown and Sharon Bonner-Brown)-

Publisher

American Society for Microbiology

Subject

Virology,Microbiology

Reference70 articles.

1. World Health Organization. 2014. Antimicrobial resistance: global report on surveillance 2014. World Health Organization, Geneva, Switzerland.

2. World Health Organization. 2019. Global tuberculosis report 2019. World Health Organization, Geneva, Switzerland.

3. Novel classes of antibiotics or more of the same?

4. Challenges of Antibacterial Discovery

5. ESKAPEing the labyrinth of antibacterial discovery

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