Improved Acetylating Radioenzymatic Assay of Amikacin, Tobramycin, and Sisomicin in Serum-Reference-Cited by-同舟云学术

Improved Acetylating Radioenzymatic Assay of Amikacin, Tobramycin, and Sisomicin in Serum

Published:1975-03 Issue:3 Volume:7 Page:374-376
ISSN:0066-4804
Container-title:Antimicrobial Agents and Chemotherapy
language:en
Short-container-title:Antimicrob Agents Chemother

Author:

Stevens Paul¹,Young Lowell S.¹,Hewitt William L.¹

Affiliation:

1. Departments of Medicine and Pharmacology, University of California at Los Angeles School of Medicine, Los Angeles, California 90024

Abstract

The acetylating radioenzymatic assay of aminoglycosides was modified by using [ 3 H]acetyl coenzyme A as cosubstrate. This modification reduces the cost of the method by at least one-half without sacrificing rapidity or accuracy.

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology

Link

https://journals.asm.org/doi/pdf/10.1128/AAC.7.3.374

Reference7 articles.

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2. Enzymatic acetylation as a means of determining serum aminoglycoside concen- trations;Haas M. J.;Antimicrob. Agents Chemother.,1973

3. The release of enzymes by osmotic shock from Escherichia coli in exponential phase;Nossal N. G.;J. Biol. Chem.,1966

4. Chloramphenicol-, dihydrostreptomycin-, and kanamycin-inactivating enzymes from multiple drug-resistant Escherichia coli carrying episome "R;Okamoto S.;Nature (London),1965

5. Enzymatic assay of gentamicin and kanamycin in body fluids;Shaw W. V.;J. Clin. Res.,1972

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