Phosphonoacetic Acid-Resistant Herpes Simplex Virus Infection in Hairless Mice-Reference-Cited by-同舟云学术

Phosphonoacetic Acid-Resistant Herpes Simplex Virus Infection in Hairless Mice

Published:1975-03 Issue:3 Volume:7 Page:289-293
ISSN:0066-4804
Container-title:Antimicrobial Agents and Chemotherapy
language:en
Short-container-title:Antimicrob Agents Chemother

Author:

Klein Richard J.¹,Friedman-Kien Alvin E.¹

Affiliation:

1. Departments of Microbiology and Dermatology, New York University School of Medicine, New York, New York 10016

Abstract

Phosphonoacetic acid (PAA)-resistant type 1 herpes simplex virus population was isolated by repeated passage of the virus in the presence of this inhibitor. Hairless mice infected percutaneously with the inhibitor-resistant or the parental inhibitor-susceptible virus were treated intraperitoneally with PAA and 9-β- d -arabinofuranosyl-adenine by using several different dosage schedules. Whereas 9-β- d -arabinofuranosyl-adenine was effective both in the PAA-susceptible and PAA-resistant herpes simplex virus-induced skin infection, PAA suppressed only the infection induced by the parental PAA-susceptible virus.

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology

Link

https://journals.asm.org/doi/pdf/10.1128/AAC.7.3.289

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