A Large-Scale Whole-Genome Comparison Shows that Experimental Evolution in Response to Antibiotics Predicts Changes in Naturally Evolved Clinical Pseudomonas aeruginosa

Author:

Wardell Samuel J. T.1ORCID,Rehman Attika1,Martin Lois W.1,Winstanley Craig2ORCID,Patrick Wayne M.13ORCID,Lamont Iain L.1ORCID

Affiliation:

1. Department of Biochemistry, University of Otago, Dunedin, New Zealand

2. Institute of Infection and Global Health, University of Liverpool, Liverpool, United Kingdom

3. School of Biological Sciences, Victoria University of Wellington, Wellington, New Zealand

Abstract

Pseudomonas aeruginosa is an opportunistic pathogen that causes a wide range of acute and chronic infections. An increasing number of isolates have mutations that make them antibiotic resistant, making treatment difficult. To identify resistance-associated mutations, we experimentally evolved the antibiotic-sensitive strain P. aeruginosa PAO1 to become resistant to three widely used antipseudomonal antibiotics, namely, ciprofloxacin, meropenem, and tobramycin.

Funder

Manatu Hauora | Health Research Council of New Zealand

University of Otago

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology

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