Polymorphisms in the Genes Encoding Chemokine Receptor 5, Interleukin-10, and Monocyte Chemoattractant Protein 1 Contribute to Cytomegalovirus Reactivation and Disease after Allogeneic Stem Cell Transplantation-Reference-Cited by-同舟云学术

Polymorphisms in the Genes Encoding Chemokine Receptor 5, Interleukin-10, and Monocyte Chemoattractant Protein 1 Contribute to Cytomegalovirus Reactivation and Disease after Allogeneic Stem Cell Transplantation

Published:2006-05 Issue:5 Volume:44 Page:1847-1850
ISSN:0095-1137
Container-title:Journal of Clinical Microbiology
language:en
Short-container-title:J Clin Microbiol

Author:

Loeffler Juergen¹,Steffens Michael²,Arlt Eva-Maria³,Toliat Mohammad-Reza⁴,Mezger Markus¹,Suk Anita⁴,Wienker Thomas F.²,Hebart Holger³,Nürnberg Peter⁴,Boeckh Michael⁵,Ljungman Per⁶,Trenschel Rudolf⁷,Einsele Hermann¹

Affiliation:

1. Julius-Maximilians-Universität Würzburg, Medizinische Klinik II, 97070 Würzburg, Germany

2. Institut für Medizinische Biometrie, Informatik und Epidemiologie der Rheinischen Friedrich-Wilhelms-Universität, 53105 Bonn, Germany

3. Eberhard-Karls-Universität, Medizinische Klinik II, 72076 Tübingen, Germany

4. Cologne Center for Genomics, 50674 Cologne, Germany

5. Fred Hutchinson Cancer Research Center, Seattle, Washington 98109

6. Department of Hematology, Karolinska University Hospital/Huddinge Hospital, Stockholm, Sweden

7. Medizinische Universitätsklinik Essen, 45123 Essen, Germany

Abstract

ABSTRACT We analyzed 90 polymorphisms in 17 genes related to immune function for association with human cytomegalovirus (HCMV) reactivation and disease in patients after allogeneic stem cell transplantation. We found relevant markers (i) in CCR5 and IL-10 genes conferring a higher risk for the development of HCMV disease and (ii) in the MCP1 gene associated with HCMV reactivation. Testing of high-risk patients for the presence of these single-nucleotide polymorphisms might be useful for individualizing antiviral prophylaxis.

Publisher

American Society for Microbiology

Subject

Microbiology (medical)

Link

https://journals.asm.org/doi/pdf/10.1128/JCM.44.5.1847-1850.2006

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