Wild-Type Circadian Rhythmicity Is Dependent on Closely Spaced E Boxes in the Drosophila timeless Promoter-Reference-Cited by-同舟云学术

Wild-Type Circadian Rhythmicity Is Dependent on Closely Spaced E Boxes in the Drosophila timeless Promoter

Published:2001-02-15 Issue:4 Volume:21 Page:1207-1217
ISSN:0270-7306
Container-title:Molecular and Cellular Biology
language:en
Short-container-title:Mol Cell Biol

Author:

McDonald Michael J.¹,Rosbash Michael¹²,Emery Patrick¹²

Affiliation:

1. Department of Biology, National Science Foundation Center for Biological Timing, 1 and

2. Howard Hughes Medical Institute, Brandeis University, 2 Waltham, Massachusetts 02454

Abstract

ABSTRACT Transcriptional regulation plays an important role in Drosophila melanogaster circadian rhythms. The period promoter has been well studied, but the timeless promoter has not been analyzed in detail. Mutagenesis of the canonical E box in the timeless promoter reduces but does not eliminate timeless mRNA cycling or locomotor activity rhythms. This is because there are at least two other cis -acting elements close to the canonical E box, which can also be transactivated by the circadian transcription factor dCLOCK. These E-box-like sequences cooperate with the canonical E-box element to promote high-amplitude transcription, which is necessary for wild-type rhythmicity.

Publisher

American Society for Microbiology

Subject

Cell Biology,Molecular Biology

Link

https://journals.asm.org/doi/pdf/10.1128/MCB.21.4.1207-1217.2001

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