Multicenter Evaluation of the Unyvero Platform for Testing Bronchoalveolar Lavage Fluid-Reference-Cited by-同舟云学术

Multicenter Evaluation of the Unyvero Platform for Testing Bronchoalveolar Lavage Fluid

Published:2021-02-18 Issue:3 Volume:59 Page:
ISSN:0095-1137
Container-title:Journal of Clinical Microbiology
language:en
Short-container-title:J Clin Microbiol

Author:

Klein Matthias¹,Bacher Johannes¹,Barth Sandra¹,Atrzadeh Faranak²,Siebenhaller Katja¹,Ferreira Inês³,Beisken Stephan³,Posch Andreas E.³,Carroll Karen C.⁴,Wunderink Richard G.⁵,Qi Chao⁶,Wu Fann⁷,Hardy Dwight J.⁸,Patel Robin⁹¹⁰^ORCID,Sims Matthew D.¹¹¹²¹³^ORCID

Affiliation:

1. Curetis GmbH, Holzgerlingen, Germany

2. OpGen, Inc., Gaithersburg, Maryland, USA

3. Ares Genetics GmbH, Vienna, Austria

4. The Johns Hopkins University School of Medicine, Baltimore, Maryland, USA

5. Division of Pulmonary and Critical Care Medicine, Department of Medicine, Northwestern University Feinberg School of Medicine, Chicago, Illinois, USA

6. Clinical Microbiology Laboratory, Department of Pathology, Northwestern University Feinberg School of Medicine, Chicago, Illinois, USA

7. Columbia University Medical Center, New York, New York, USA

8. University of Rochester Medical Center, Rochester, New York, USA

9. Division of Clinical Microbiology, Mayo Clinic, Rochester, Minnesota, USA

10. Division of Infectious Diseases, Department of Medicine, Mayo Clinic, Rochester, Minnesota, USA

11. Beaumont Hospital, Royal Oak, Section of Infectious Diseases and International Medicine, Royal Oak, Michigan, USA

12. Department of Internal Medicine, Oakland University William Beaumont School of Medicine, Rochester, Michigan, USA

13. Department of Foundational Medical Studies, Oakland University William Beaumont School of Medicine, Rochester, Michigan, USA

Abstract

Bronchoalveolar lavage (BAL) culture is a standard, though time-consuming, approach for identifying microorganisms in patients with severe lower respiratory tract infections. The sensitivity of BAL culture is relatively low, and prior antimicrobial therapy decreases the sensitivity further, leading to overuse of empirical antibiotics.

Funder

Curetis GmbH

Publisher

American Society for Microbiology

Subject

Microbiology (medical)

Link

https://journals.asm.org/doi/pdf/10.1128/JCM.02497-20

Reference36 articles.

1. Usefulness of sputum gram stain for etiologic diagnosis in community-acquired pneumonia: a systematic review and meta-analysis

2. Is the Gram Stain Useful in the Microbiologic Diagnosis of VAP? A Meta-analysis

3. Bacterial Yield from Quantitative Cultures of Bronchoalveolar Lavage Fluid in Patients with Pneumonia on Antimicrobial Therapy