Abstract
Evidence is presented to indicate that Plasmodium berghei merozoites, but not trophozotites, have an antiphagocytic capsule. The capsule appears to form around the developing merozoties of the schizont in the parasitophorous vacuole. Serum from animals immune to P. berghei reacts with this capsule. After reaction with immune serum, the antiphagocytic action of the capsule is lost. By the process of binding serum protein, the capsule becomes electron dense and can be readily visuallzed as the surface coat by electron microscopy. At physiological temperatures, phagocytosis by macrophages rapidly follows adhesion of antibody-coated parasites. Both tight and loose phagosomes are formed.
Publisher
American Society for Microbiology
Subject
Infectious Diseases,Immunology,Microbiology,Parasitology
Reference25 articles.
1. Structure and invasive behavior of Plasmodium knowlesi merozoites in vitro;Bannister L. H.;Parasitology,1975
2. An electron microscopic study of phagocytosis of Candida albicans by polymorphonuclear leukocytes;Belcher R. W.;Lab. Invest.,1973
3. Plasmodium berghei: adherence and phagocytosis by rat macrophages in vitro;Chow J. S.;Exp. Parasitol.,1972
4. Antibody-induced ultrastructural changes of malarial sporozoites;Cochrane A. H.;J. Immunol.,1976
5. Davis B. D. R. Dulbecco H. N. Eisen H. S. Ginsberg W. B. Wood and M. McCorly. 1973. Microbiology 2nd ed. p. 694-706. Harper & Row Publishers Hagerstown Md.
Cited by
23 articles.
订阅此论文施引文献
订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献