MCR-1 and OXA-48 In Vivo Acquisition in KPC-Producing Escherichia coli after Colistin Treatment-Reference-Cited by-同舟云学术

MCR-1 and OXA-48 In Vivo Acquisition in KPC-Producing Escherichia coli after Colistin Treatment

Published:2017-08 Issue:8 Volume:61 Page:
ISSN:0066-4804
Container-title:Antimicrobial Agents and Chemotherapy
language:en
Short-container-title:Antimicrob Agents Chemother

Author:

Beyrouthy Racha¹²³,Robin Frederic¹²³,Lessene Aude⁴,Lacombat Igor⁵,Dortet Laurent⁶⁷⁸,Naas Thierry⁶⁷⁸^ORCID,Ponties Valérie⁹,Bonnet Richard¹²³

Affiliation:

1. CHU Clermont-Ferrand, Laboratoire de Bactériologie Clinique, Clermont-Ferrand, France

2. Centre National de Référence de la Résistance aux Antibiotiques, laboratoire associé, Clermont-Ferrand, France

3. Université Clermont Auvergne, UMR INSERM 1071, USC INRA2018, Clermont-Ferrand, France

4. Laboratoire Jacques Cartier, Hôpital privé Jacques Cartier, Massy, France

5. Service de Réanimation, Hôpital privé Jacques Cartier, Massy, France

6. EA7361, Université Paris-Sud, Université Paris-Saclay, LabEx Lermit, Bacteriology-Hygiene Unit, APHP, Hôpital Bicêtre, Le Kremlin-Bicêtre, France

7. Associated French National Reference Center for Antibiotic Resistance: Carbapenemase-Producing Enterobacteriaceae, Le Kremlin-Bicêtre, France

8. Evolution and Ecology of Resistance to Antibiotics Unit, Institut Pasteur-APHP-Université Paris Sud, Paris, France

9. Santé Publique France, Saint-Maurice, France

Abstract

ABSTRACT The spread of mcr-1 -encoding plasmids into carbapenem-resistant Enterobacteriaceae raises concerns about the emergence of untreatable bacteria. We report the acquisition of mcr-1 in a carbapenem-resistant Escherichia coli strain after a 3-week course of colistin in a patient repatriated to France from Portugal. Whole-genome sequencing revealed that the Klebsiella pneumoniae carbapenemase-producing E. coli strain acquired two plasmids, an IncL OXA-48-encoding plasmid and an IncX4 mcr-1 -encoding plasmid. This is the first report of mcr-1 in carbapenemase-encoding bacteria in France.

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology

Link

https://journals.asm.org/doi/pdf/10.1128/AAC.02540-16

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