Three-Dimensional Reconstruction of the Hepatitis C Virus Envelope Glycoprotein E1E2 Heterodimer by Electron Microscopic Analysis-Reference-Cited by-同舟云学术

Three-Dimensional Reconstruction of the Hepatitis C Virus Envelope Glycoprotein E1E2 Heterodimer by Electron Microscopic Analysis

Published:2023-01-31 Issue:1 Volume:97 Page:
ISSN:0022-538X
Container-title:Journal of Virology
language:en
Short-container-title:J Virol

Author:

Kanai Tapan¹²,Hu Zongyi³,Yang Renbin¹²^ORCID,Wu Weimin¹²,Wang Ziqiu¹²,Ma Christopher D.³^ORCID,Sanchez-Meza Jaime³,Law Mansun⁴,Houghton Michael⁵,Law John Lokman⁵^ORCID,Logan Michael⁵,de Val Natalia¹²,Liang T. Jake³^ORCID

Affiliation:

1. Center for Molecular Microscopy, Center for Cancer Research, National Cancer Institute, NIH, Frederick, Maryland, USA

2. Cancer Research Technology Program, Frederick National Laboratory for Cancer Research, Frederick, Maryland, USA

3. Liver Diseases Branch, National Institute of Diabetes and Digestive and Kidney Diseases, NIH, Bethesda, Maryland, USA

4. Department of Immunology and Microbiology, The Scripps Research Institute, La Jolla, California, USA

5. Li Ka Shing Applied Virology Institute, University of Alberta, Edmonton, Canada

Abstract

Recombinant HCV E1E2 heterodimer is being developed as a vaccine candidate. Using electron microscopy, we demonstrated unique features of E1E2 in complex with various neutralizing antibodies and small molecule inhibitors that are important to understanding its antigenicity and induction of immune response.

Funder

HHS | National Institutes of Health

Publisher

American Society for Microbiology

Subject

Virology,Insect Science,Immunology,Microbiology

Link

https://journals.asm.org/doi/pdf/10.1128/jvi.01788-22

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