Vaccines That Reduce Viral Shedding Do Not Prevent Transmission of H1N1 Pandemic 2009 Swine Influenza A Virus Infection to Unvaccinated Pigs-Reference-Cited by-同舟云学术

Vaccines That Reduce Viral Shedding Do Not Prevent Transmission of H1N1 Pandemic 2009 Swine Influenza A Virus Infection to Unvaccinated Pigs

Published:2021-01-28 Issue:4 Volume:95 Page:
ISSN:0022-538X
Container-title:Journal of Virology
language:en
Short-container-title:J Virol

Author:

Everett Helen E.¹^ORCID,van Diemen Pauline M.¹,Aramouni Mario²,Ramsay Andrew¹,Coward Vivien J.¹,Pavot Vincent²^ORCID,Canini Laetitia³^ORCID,Holzer Barbara⁴,Morgan Sophie⁴,Woolhouse Mark E. J.³^ORCID,Tchilian Elma⁴^ORCID,Brookes Sharon M.¹^ORCID,Brown Ian H.¹,Charleston Bryan⁴^ORCID,Gilbert Sarah²^ORCID,

Affiliation:

1. APHA-Weybridge, New Haw, Addlestone, United Kingdom

2. The Jenner Institute, Nuffield Department of Medicine, University of Oxford, Oxford, United Kingdom

3. Usher Institute, Ashworth Laboratories, University of Edinburgh, Edinburgh, United Kingdom

4. The Pirbright Institute, Pirbright, Woking, United Kingdom

Abstract

This study was designed to determine whether vaccination of pigs with conventional WIV or virus-vectored vaccines reduces pH1N1 swine influenza virus shedding following challenge and can prevent transmission to naive in-contact animals. Even when viral shedding was significantly reduced following challenge, infection was transmissible to susceptible cohoused recipients.

Funder

UKRI | Biotechnology and Biological Sciences Research Council

Department for Environment, Food and Rural Affairs, UK Government

Publisher

American Society for Microbiology

Subject

Virology,Insect Science,Immunology,Microbiology

Link

https://journals.asm.org/doi/pdf/10.1128/JVI.01787-20

Reference41 articles.

1. Sowing the Seeds of a Pandemic? Mammalian Pathogenicity and Transmissibility of H1 Variant Influenza Viruses from the Swine Reservoir

2. Swine Influenza A Viruses and the Tangled Relationship with Humans