Copurification of Leptospira interrogans serovar pomona hemolysin and sphingomyelinase C

Author:

Bernheimer A W,Bey R F

Abstract

The hemolytic and sphingomyelinase C activities of supernatants of cultures of Leptospira interrogans serovar pomona tended to copurify when isoelectric fractionation was carried out. Both activities focused primarily at pH 8.1. Considered in conjunction with other circumstantial evidence, the results led to the conclusion that sphingomyelinase C is responsible for hemolysis.

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Immunology,Microbiology,Parasitology

Reference26 articles.

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2. The significance of leptospiral hemolysin in the pathogenesis of Leptospira pomona infections;Bauer D. C.;J. Infect. Dis.,1961

3. Haemolysis of white rat erythrocytes by pathogenic and saprophytic strains of leptospires;Bazovska S.;Cs. Epidemiol. Mikrobiol. Immunol.,1977

4. Sphingomyelinase activity of leptospira cultures;Bazovska S.;Cs. Epidemiol. Microbiol. Immunol.,1978

5. Properties of a toxin from the sea anemone Stoichactis helianthus, including specific binding to sphingomyelin;Bernheinmer A. W.;Proc. Natl. Acad. Sci. USA,1976

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