Dominant Nonresponsiveness to Helicobacter pylori Infection Is Associated with Production of Interleukin 10 but Not Gamma Interferon-Reference-Cited by-同舟云学术

Dominant Nonresponsiveness to Helicobacter pylori Infection Is Associated with Production of Interleukin 10 but Not Gamma Interferon

Published:2000-08 Issue:8 Volume:68 Page:4802-4804
ISSN:0019-9567
Container-title:Infection and Immunity
language:en
Short-container-title:Infect Immun

Author:

Sutton Philip¹,Kolesnikow Tassia¹,Danon Stephen¹,Wilson John¹,Lee Adrian¹

Affiliation:

1. School of Microbiology and Immunology, University of New South Wales, Sydney, New South Wales 2052, Australia

Abstract

ABSTRACT Helicobacter pylori -induced gastritis is an essential precursor lesion for the development of peptic ulcers or gastric adenocarcinoma. We demonstrate that nonresponsiveness to H. pylori SS1 infection is dominantly inherited in mice. F 1 hybrid crosses between a nonresponder mouse and three responder strains all possessed the nonresponder phenotype. Secretion of interleukin-10 but not gamma interferon was associated with nonresponsiveness to infection.

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Immunology,Microbiology,Parasitology

Link

https://journals.asm.org/doi/pdf/10.1128/IAI.68.8.4802-4804.2000

Reference23 articles.

1. Effects of rebamipide on production of several cytokines by human peripheral blood mononuclear cells;Aihara M.;Dig. Dis. Sci.,1998

2. The role of the HLA-DQA1 gene in resistance to atrophic gastritis and gastric adenocarcinoma induced by Helicobacter pylori infection;Azuma T.;Cancer,1998

3. Lymphocytes in the human gastric mucosa during Helicobacter pylori have a T helper cell 1 phenotype;Bamford K. B.;Gastroenterology,1998

4. Symptomatic and endoscopic duodenal ulcer relapse rates 12 months following Helicobacter pylori eradication treatment with omeprazole and amoxycillin with or without metronidazole;Bell G. D.;Aliment. Pharmacol. Ther.,1996

5. Rapid development of severe hyperplastic gastritis with gastric epithelial dedifferentiation in Helicobacter felis-infected IL-10(−/−) mice;Berg D. J.;Am. J. Pathol.,1998

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