Affiliation:
1. Department of Microbiology and Immunology, Wake Forest University School of Medicine, Winston-Salem, North Carolina 27157
Abstract
ABSTRACT
Many respiratory isolates of
Pseudomonas aeruginosa
from cystic fibrosis patients are mucoid (alginate producing) yet lack flagella. It was hypothesized that an alginate regulator inhibits flagellar gene expression. Mutations in
algB
,
algR
, and
algT
resulted in nonmucoid derivatives, yet
algT
mutants expressed flagella. AlgT-dependent control of flagellum synthesis occurred through inhibition of
fliC
but not
rpoN
transcription.
Publisher
American Society for Microbiology
Subject
Molecular Biology,Microbiology
Cited by
120 articles.
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