Mutations in Catabolite Control Protein CcpA Showing Glucose-Independent Regulation in Bacillus megaterium-Reference-Cited by-同舟云学术

Mutations in Catabolite Control Protein CcpA Showing Glucose-Independent Regulation in Bacillus megaterium

Published:1999-12-15 Issue:24 Volume:181 Page:7634-7638
ISSN:0021-9193
Container-title:Journal of Bacteriology
language:en
Short-container-title:J Bacteriol

Author:

Küster-Schöck Elke¹,Wagner Andrea¹,Völker Uwe²,Hillen Wolfgang¹

Affiliation:

1. Lehrstuhl für Mikrobiologie, Friedrich-Alexander-Universität Erlangen-Nürnberg, 91058 Erlangen,1 and

2. Laboratorium für Mikrobiologie, Philipps-Universität Marburg and Max-Planck-Institut für Terrestrische Mikrobiologie, Marburg,2 Federal Republic of Germany

Abstract

ABSTRACT We identified five single amino acid exchanges in CcpA that lead to permanent repression of the xylose utilization genes in the absence of glucose. Other proteins from the CcpA regulon also show glucose-independent regulation in the mutants. The mutant CcpA proteins bind to the DNA target catabolite responsive elements without the corepressor HPr-Ser-P.

Publisher

American Society for Microbiology

Subject

Molecular Biology,Microbiology

Link

https://journals.asm.org/doi/pdf/10.1128/JB.181.24.7634-7638.1999

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