Genetics of resistance to African trypanosomes: role of the H-2 locus in determining resistance to infection with Trypanosoma rhodesiense

Author:

Levine R F,Mansfield J M

Abstract

Susceptibility and resistance to Trypanosoma rhodesiense infections in inbred and H-2 congenic strains of mice were studied. Mean survival times and patterns of parasitemia were examined. C3HeB/FeJ mice were highly susceptible; CBA/J, A/J, and BALB/cByJ mice displayed an intermediate level of susceptibility; whereas C57BL/10 mice were highly resistant. H-2 congenic strains with the BL/10 background resembled the BL/10 parental type, thereby suggesting that the major histocompatibility complex does not play a major role in regulating resistance and susceptibility to infection with T. rhodesiense.

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Immunology,Microbiology,Parasitology

Reference28 articles.

1. Histocompatibility-linked IR genes;Benacerraf B.;Science,1972

2. Regulation ofleishmania populations within the host. HI. Genetic control of acute susceptibility of mice to Leishmania donovani infection;Bradley D. J.;Clin. Exp. Immunol.,1977

3. Regulation of Leishmania populations within the host. HI. Mapping of the locus controlling susceptibility to visceral leishmani in the mouse;Bradley D. J.;Clin. Exp. Immunol.,1979

4. Trypanosoma brucei: influence of host strain and parasite antigenic type on infections in mice;Clayton C. E.;Exp. Parasitol.,1978

5. The course of a Plasmodium berghei infection in six different mouse strains;Eling W.;Parasitenkunde,1977

同舟云学术

1.学者识别学者识别

2.学术分析学术分析

3.人才评估人才评估

"同舟云学术"是以全球学者为主线,采集、加工和组织学术论文而形成的新型学术文献查询和分析系统,可以对全球学者进行文献检索和人才价值评估。用户可以通过关注某些学科领域的顶尖人物而持续追踪该领域的学科进展和研究前沿。经过近期的数据扩容,当前同舟云学术共收录了国内外主流学术期刊6万余种,收集的期刊论文及会议论文总量共计约1.5亿篇,并以每天添加12000余篇中外论文的速度递增。我们也可以为用户提供个性化、定制化的学者数据。欢迎来电咨询!咨询电话:010-8811{复制后删除}0370

www.globalauthorid.com

TOP

Copyright © 2019-2024 北京同舟云网络信息技术有限公司
京公网安备11010802033243号  京ICP备18003416号-3