Affiliation:
1. Lilly Research Laboratories, Division of Eli Lilly and Company, Indianapolis, Indiana 46206
Abstract
Early response of
Escherichia coli
to minimal inhibitory concentrations of 112883, BL-P1654, and carbenicillin was determined by [
14
C]leucine uptake and scanning electron microscopy morphology studies. [
14
C]leucine uptake was inhibited later by carbenicillin than by BL-P1654 or 112883. Cellular swelling at 30 min, septal region swelling, and lysis were the progressive morphological changes with BL-P1654 and 112883. Carbenicillin-treated cells showed septal region swelling, beaded chains, and lysis.
Publisher
American Society for Microbiology
Subject
Infectious Diseases,Pharmacology (medical),Pharmacology
Reference10 articles.
1. Interaction of penicillin with the bacterial cell: penicillinbinding proteins and penicillin-sensitive enzymes;Blumberg P. M.;Bacteriol. Rev.,1974
2. Septum formation in Escherichia coli: characterization of septal structure and the effects of antibiotics on cell division;Burdett I. D. J.;J. Bacteriol.,1974
3. Evaluation of antibiotic efficacy using electron microscopy: morphological effects of guanylureido cephalosporin, chlorobenzoylureido cephalosporin, BL-P1654, and carbenicillin on Pseudomonas aeruginosa;Ellis L. F.;Antimicrob. Agents Chemother.,1976
4. Antibiotic sensitivity testing. Report of an international collaborative study;Ericsson H. M.;Acta Pathol. Microbiol. Scand. Sect. B,1971
5. A comparison of the effects of ampicillin on Escherichia coli and Proteus mirabilis;Greenwood D.;J. Med. Microbiol.,1969
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