Susceptibility Pattern and Molecular Type of Species-Specific Candida in Oropharyngeal Lesions of Indian Human Immunodeficiency Virus-Positive Patients

Author:

Abdul Lattif Ali1,Banerjee Uma2,Prasad Rajendra1,Biswas Ashutosh3,Wig Naveet3,Sharma Neeraj4,Haque Absarul4,Gupta Nivedita4,Baquer Najma Z.1,Mukhopadhyay Gauranga4

Affiliation:

1. School of Life Sciences

2. Department of Microbiology

3. Department of Medicine, All India Institute of Medical Sciences, New Delhi, India

4. Special Centre for Molecular Medicine, Jawaharlal Nehru University

Abstract

ABSTRACT A study of oropharyngeal candidiasis (OPC) in Indian human immunodeficiency virus (HIV)/AIDS patients was conducted over a period of 15 months. This study revealed that 75% of the HIV/AIDS patients had OPC. MIC testing revealed that 5% of the Candida isolates were fluconazole resistant. A correlation between CD4 + -T-cell counts and development of OPC in HIV/AIDS patients was also observed. Molecular typing of C. albicans isolates showed that all were genetically unrelated.

Publisher

American Society for Microbiology

Subject

Microbiology (medical)

Reference39 articles.

1. Aggarwal O. P. A. K. Sharma and A. Inddrayan (ed.). 1997. HIV/AIDS research in India p. 713-720. Ministry of Health and Family Welfare Government of India New Delhi.

2. Anonymous. 1999. Guidelines for preparing standard operating procedure for laboratory diagnosis of HIV-opportunistic infection p. 49-69. W. H. O. Collaboration Centre for Training on HIV/AIDS. Clinical management and counseling. Ministry of Public Health Bangkok Thailand.

3. Anonymous. 1999. Laboratory diagnosis of HIV-opportunistic infections p. 93-105. W. H. O. Collaboration Centre for Training on HIV/AIDS. Clinical management and counseling. Ministry of Public Health Bangkok Thailand.

4. Brambilla, A. M., A Castagna., B. Nocita, H. Hasson, E. Boeri, F. Veglia, and A. Lazzarin. 2001. Relation between CD4 cell counts and HIV RNA levels at onset of opportunistic infections. J. Acquir. Immun. Defic. Syndr.27:44-48.

5. Fidel, P. L., Jr. 2002. Immunity to Candida. Oral Dis.8:69-75.

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