Aspergillus fumigatus Empyema, Arthritis, and Calcaneal Osteomyelitis in a Lung Transplant Patient Successfully Treated with Posaconazole

Author:

Lodge Barbara Alexander1,Ashley Elizabeth Dodds1,Steele Mark P.2,Perfect John R.1

Affiliation:

1. Divisions of Infectious Diseases and International Health

2. Pulmonary and Critical Care Medicine, Department of Medicine, Duke University Medical Center, Durham, North Carolina

Abstract

ABSTRACT A 64-year-old male with Aspergillus fumigatus infection that had disseminated from the lung to the ankle and adjacent bone was treated successfully with posaconazole after therapy with itraconazole and amphotericin B lipid complex failed. Marked clinical improvement occurred within 6 weeks of initiation of posaconazole therapy; after 6 months, infection had resolved at all sites. The patient has had no recurrence of infection.

Publisher

American Society for Microbiology

Subject

Microbiology (medical)

Reference9 articles.

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2. Faure, B. T., J. X. Biondi, J. P. Flanagan, and R. Clarke. 1990. Aspergillar osteomyelitis of the acetabulum. A case report and review of the literature. Orthop. Rev.19:58-64.

3. Hummel, M., S. Schuler, U. Weber, G. Schwertlick, S. Hempel, D. Theiss, W. Rees, J. Mueller, and R. Hetzer. 1993. Aspergillosis with aspergillus osteomyelitis and diskitis after heart transplantation: surgical and medical management. J. Heart Lung Transplant.12:599-603.

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