Human Monoclonal Antibody Fragment Specific for Glycoprotein G in Herpes Simplex Virus Type 2 with Applications for Serotype-Specific Diagnosis-Reference-Cited by-同舟云学术

Human Monoclonal Antibody Fragment Specific for Glycoprotein G in Herpes Simplex Virus Type 2 with Applications for Serotype-Specific Diagnosis

Published:2004-03 Issue:3 Volume:42 Page:1250-1253
ISSN:0095-1137
Container-title:Journal of Clinical Microbiology
language:en
Short-container-title:J Clin Microbiol

Author:

Bugli Francesca¹,Manzara Stefania¹,Torelli Riccardo¹,Graffeo Rosalia¹,Santangelo Rosaria¹,Cattani Paola¹,Fadda Giovanni¹

Affiliation:

1. Istituto di Microbiologia, Università Cattolica del Sacro Cuore, 00168 Rome, Italy

Abstract

ABSTRACT A combinatorial library was used to select a human monoclonal antibody fragment (Fab) with high affinity for G glycoprotein in herpes simplex virus type 2 (HSV-2). Tests with 112 clinical specimens demonstrated successful discrimination between HSV-2 and HSV-1, showing the potential of Fab as a low-cost tool for HSV subtyping in clinical diagnosis.

Publisher

American Society for Microbiology

Subject

Microbiology (medical)

Link

https://journals.asm.org/doi/pdf/10.1128/JCM.42.3.1250-1253.2004

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