Chronic Leptin Deficiency Improves Tolerance of Physiological Damage and Host-Pathogen Cooperation during Yersinia pseudotuberculosis Infection-Reference-Cited by-同舟云学术

Chronic Leptin Deficiency Improves Tolerance of Physiological Damage and Host-Pathogen Cooperation during Yersinia pseudotuberculosis Infection

Published:2022-09-15 Issue:9 Volume:90 Page:
ISSN:0019-9567
Container-title:Infection and Immunity
language:en
Short-container-title:Infect Immun

Author:

Sanchez Karina K.¹,Troha Katia¹^ORCID,Mu Andre¹,Redford Samuel E.¹²,McCarville Justin L.¹,Insenga Arianna¹,Stengel Sarah¹,Lee Yujung Michelle¹,Ayres Janelle S.¹^ORCID

Affiliation:

1. Molecular and Systems Physiology Lab, Gene Expression Lab, Nomis Center for Immunobiology and Microbial Pathogenesis, Salk Institute for Biological Studies, La Jolla, California, USA

2. Division of Biological Sciences, University of California, San Diego, La Jolla, California, USA

Abstract

To combat infections, hosts employ a combination of antagonistic and cooperative defense strategies. The former refers to pathogen killing mediated by resistance mechanisms, while the latter refers to physiological defense mechanisms that promote host health during infection independent of pathogen killing, leading to an apparent cooperation between the host and the pathogen.

Funder

HHS | National Institutes of Health

Gouvernement du Canada | Canadian Institutes of Health Research

NOMIS Stiftung

Pioneer Fund

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Immunology,Microbiology,Parasitology

Link

https://journals.asm.org/doi/pdf/10.1128/iai.00242-22

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