Affiliation:
1. Departments of Molecular Microbiology
2. Pediatrics, Washington University School of Medicine, St. Louis, Missouri 63110
Abstract
ABSTRACT
Previously, we established an intranasal mouse model of
Klebsiella pneumoniae
infection and validated its utility using a highly virulent wild-type strain and an avirulent capsular polysaccharide mutant. In the present study we compare the host responses to both infections by examining cytokine production, cellular infiltration, pulmonary histology, and intranasal immunization.
Publisher
American Society for Microbiology
Subject
Infectious Diseases,Immunology,Microbiology,Parasitology
Reference32 articles.
1. THE PATHOGENICITY OF
KLEBSIELLA PNEUMONIAE
FOR MICE: THE RELATIONSHIP TO THE QUANTITY AND RATE OF PRODUCTION OF TYPE-SPECIFIC CAPSULAR POLYSACCHARIDE
2. Camprubi, S., S. Merino, V. J. Benedi, and J. M. Tomas. 1993. The role of the O-antigen lipopolysaccharide and capsule on an experimental Klebsiella pneumoniae infection of the rat urinary tract. FEMS Microbiol. Lett.111:9-13.
3. Chang, H.-Y., J. H. Lee, W. L. Deng, T. F. Fu, and H. L. Peng. 1996. Virulence and outer membrane properties of a galU mutant of Klebsiella pneumoniae CG43. Microb. Pathog.20:255-261.
4. Chhibber, S., S. Aggarwal, and V. Yadav. 2003. Contribution of capsular and lipopolysaccharide antigens to the pathogenesis of Klebsiella pneumoniae respiratory tract infection. Folia Microbiol.48:699-702.
5. Chhibber, S., S. Wadhwa, and V. Yadav. 2004. Protective role of liposome incorporated lipopolysaccharide antigen of Klebsiella pneumoniae in a rat model of lobar pneumonia. Jpn. J. Infect. Dis.57:150-155.