Fosmanogepix (APX001) Is Effective in the Treatment of Immunocompromised Mice Infected with Invasive Pulmonary Scedosporiosis or Disseminated Fusariosis-Reference-Cited by-同舟云学术

Fosmanogepix (APX001) Is Effective in the Treatment of Immunocompromised Mice Infected with Invasive Pulmonary Scedosporiosis or Disseminated Fusariosis

Published:2020-02-21 Issue:3 Volume:64 Page:
ISSN:0066-4804
Container-title:Antimicrobial Agents and Chemotherapy
language:en
Short-container-title:Antimicrob Agents Chemother

Author:

Alkhazraji Sondus¹,Gebremariam Teclegiorgis¹,Alqarihi Abdullah¹,Gu Yiyou¹,Mamouei Zeinab¹,Singh Shakti¹^ORCID,Wiederhold Nathan P.²^ORCID,Shaw Karen J.³,Ibrahim Ashraf S.¹⁴

Affiliation:

1. Division of Infectious Diseases, The Lundquist Institute at Harbor-University of California Los Angeles (UCLA) Medical Center and St. John’s Cardiovascular Research Center, Torrance, California, USA

2. University of Texas Health Science Center at San Antonio, San Antonio, Texas, USA

3. Amplyx Pharmaceuticals, Inc., San Diego, California, USA

4. David Geffen School of Medicine at UCLA, Los Angeles, California, USA

Abstract

There are limited treatment options for immunosuppressed patients with lethal invasive fungal infections due to Fusarium and Scedosporium . Manogepix (MGX; APX001A) is a novel antifungal that targets the conserved Gwt1 enzyme required for localization of glycosylphosphatidylinositol-anchored mannoproteins in fungi. We evaluated the in vitro activity of MGX and the efficacy of the prodrug fosmanogepix (APX001) in immunosuppressed murine models of hematogenously disseminated fusariosis and pulmonary scedosporiosis.

Funder

Amplyx Pharmaceuticals

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology

Link

https://journals.asm.org/doi/pdf/10.1128/AAC.01735-19

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