Affiliation:
1. Department of Cell and Molecular Biology, Uppsala University, Uppsala, Sweden
Abstract
Spectinomycin is a ribosome-binding antibiotic that blocks the translocation step of translation. A prevalent resistance mechanism is modification of the drug by aminoglycoside nucleotidyl transferase (ANT) enzymes of the spectinomycin-specific ANT(9) family or by enzymes of the dual-specificity ANT(3ʺ)(9) family, which also acts on streptomycin. We previously reported the structural mechanism of streptomycin modification by the ANT(3ʺ)(9) AadA from
Salmonella enterica
.
Publisher
American Society for Microbiology
Subject
Infectious Diseases,Pharmacology (medical),Pharmacology
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