Affiliation:
1. Eskitis Institute for Drug Discovery, Griffith University, Queensland, Australia
Abstract
ABSTRACT
The zoonotic malaria parasite
Plasmodium knowlesi
has recently been established in continuous
in vitro
culture. Here, the
Plasmodium falciparum
[
3
H]hypoxanthine uptake assay was adapted for
P. knowlesi
and used to determine the sensitivity of this parasite to chloroquine, cycloguanil, and clindamycin. The data demonstrate that
P. knowlesi
is sensitive to all drugs, with 50% inhibitory concentrations (IC
50
s) consistent with those obtained with
P. falciparum
. This assay provides a platform to use
P. knowlesi in vitro
for drug discovery.
Funder
Department of Health | National Health and Medical Research Council
Griffith University
EC | Seventh Framework Programme
Publisher
American Society for Microbiology
Subject
Infectious Diseases,Pharmacology (medical),Pharmacology
Cited by
14 articles.
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