Differential Antimicrobial Susceptibilities of Granulicatella adiacens and Abiotrophia defectiva

Author:

Mushtaq Ammara1,Greenwood-Quaintance Kerryl E.1,Cole Nicolynn C.1,Kohner Peggy C.1,Ihde Sherry M.1,Strand Gregory J.1,Harper Lance W.1,Virk Abinash2,Patel Robin12

Affiliation:

1. Division of Clinical Microbiology, Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, Minnesota, USA

2. Division of Infectious Diseases, Department of Medicine, Mayo Clinic, Rochester, Minnesota, USA

Abstract

ABSTRACT MICs of 25 Abiotrophia defectiva and 109 Granulicatella adiacens isolates were determined by broth microdilution. Using CLSI breakpoints, the susceptibilities of A. defectiva and G. adiacens isolates were, respectively, 24% and 34% to penicillin, 92% and 22% to ceftriaxone, 48% and 3% to cefepime, 72% and 87% to meropenem, 92% and 10% to cefotaxime, 100% and 97% to levofloxacin, 92% and 80% to clindamycin, and 24% and 50% to erythromycin. All isolates were susceptible to vancomycin. In the penicillin-susceptible subgroup, all A. defectiva isolates were susceptible to ceftriaxone; however, 62% of G. adiacens isolates were ceftriaxone nonsusceptible.

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology

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