Comparative In Vitro Activity Profiles of Novel Bis-Indole Antibacterials against Gram-Positive and Gram-Negative Clinical Isolates-Reference-Cited by-同舟云学术

Comparative In Vitro Activity Profiles of Novel Bis-Indole Antibacterials against Gram-Positive and Gram-Negative Clinical Isolates

Published:2010-09 Issue:9 Volume:54 Page:3974-3977
ISSN:0066-4804
Container-title:Antimicrobial Agents and Chemotherapy
language:en
Short-container-title:Antimicrob Agents Chemother

Author:

Butler Michelle M.¹,Williams John D.¹,Peet Norton P.¹,Moir Donald T.¹,Panchal Rekha G.²,Bavari Sina²,Shinabarger Dean L.³,Bowlin Terry L.¹

Affiliation:

1. Microbiotix, Inc., Worcester, Massachusetts

2. United States Army Medical Research Institute of Infectious Diseases, Frederick, Maryland

3. Micromyx, Kalamazoo, Michigan

Abstract

ABSTRACT Antimicrobial susceptibilities of 233 Gram-positive and 180 Gram-negative strains to two novel bis-indoles were evaluated. Both compounds were potent inhibitors of Gram-positive bacteria, with MIC 90 values of 0.004 to 0.5 μg/ml. One bis-indole, MBX 1162, exhibited potent activity against all Gram-negative strains, with MIC 90 values of 0.12 to 4 μg/ml, even against high-level-resistant pathogens, and compared favorably to all comparator antibiotics. The bis-indole compounds show promise for the treatment of multidrug-resistant clinical pathogens.

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology

Link

https://journals.asm.org/doi/pdf/10.1128/AAC.00484-10

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