Structural and Biochemical Basis for Development of Diketo Acid Inhibitors Targeting the Cap-Snatching Endonuclease of the Ebinur Lake Virus (Order: <i>Bunyavirales</i> )-Reference-Cited by-同舟云学术

Structural and Biochemical Basis for Development of Diketo Acid Inhibitors Targeting the Cap-Snatching Endonuclease of the Ebinur Lake Virus (Order: Bunyavirales )

Published:2022-04-13 Issue:7 Volume:96 Page:
ISSN:0022-538X
Container-title:Journal of Virology
language:en
Short-container-title:J Virol

Author:

Kuang Wenhua¹²,Zhang Huanyu²,Cai Yan³⁴,Zhang Guilin⁵,Deng Fei²^ORCID,Li Hailong⁵,Zhou Yiwu¹,Wang Manli²,Gong Peng⁶⁷^ORCID,Guo Yu³^ORCID,Hu Zhihong²^ORCID

Affiliation:

1. Department of Forensic Medicine, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China

2. State Key Laboratory of Virology, Wuhan Institute of Virology Chinese Academy of Sciences, Wuhan, Hubei, China

3. State Key Laboratory of Medicinal Chemical Biology, College of Life Sciences, Nankai University, Tianjin, China

4. Tianjin International Joint Academy of Biotechnology and Medicine, Tianjin, China

5. Center for Disease Control and Prevention of Xinjiang Military Command, Urumqi, Xinjiang, China

6. Key Laboratory of Special Pathogens and Biosafety, Wuhan Institute of Virology, Center for Biosafety Mega-Science, Chinese Academy of Sciences, Wuhan, Hubei, China

7. Drug Discovery Center for Infectious Diseases, Nankai University, Tianjin, China

Abstract

The Bunyavirales contain many important human pathogens such as Crimean-Congo hemorrhagic fever virus and Lassa virus that pose serious threats to public health; however, currently there are no specific antiviral drugs against these viruses. The diketo acid inhibitor L-742,001 is a potential drug as it inactivates the cap-snatching endonuclease (EN) encoded by bunyaviruses.

Funder

China Postdoctoral Science Foundation

Ministry of Science and Technology of the People's Republic of China

Hubei Natural Science Foundation for Distinguished Young Scholar

Advanced Customer Cultivation Project of Wuhan National Biosafety Laboratory, Chinese Academy of Sciences

Open Research Fund Program of the State Key Laboratory of Virology of China

Key Biosafety Science and Technology Program of Hubei Jiangxia Laboratory

Publisher

American Society for Microbiology

Subject

Virology,Insect Science,Immunology,Microbiology

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