Population Pharmacokinetics and Dosing of Ethionamide in Children with Tuberculosis-Reference-Cited by-同舟云学术

Population Pharmacokinetics and Dosing of Ethionamide in Children with Tuberculosis

Published:2020-02-21 Issue:3 Volume:64 Page:
ISSN:0066-4804
Container-title:Antimicrobial Agents and Chemotherapy
language:en
Short-container-title:Antimicrob Agents Chemother

Author:

Bjugård Nyberg Henrik¹^ORCID,Draper Heather R.²,Garcia-Prats Anthony J.²^ORCID,Thee Stephanie³,Bekker Adrie²,Zar Heather J.⁴⁵,Hooker Andrew C.¹,Schaaf H. Simon²,McIlleron Helen⁶,Hesseling Anneke C.²,Denti Paolo⁶^ORCID

Affiliation:

1. Department of Pharmaceutical Biosciences, Uppsala University, Uppsala, Sweden

2. Desmond Tutu TB Centre, Department of Paediatrics and Child Health, Faculty of Medicine and Health Sciences, Stellenbosch University, Cape Town, South Africa

3. Department of Pediatrics, Division of Pneumonology, Immunology and Intensive Care, Charité University Medicine, Berlin, Germany

4. Department of Paediatrics and Child Health, Red Cross War Memorial Children’s Hospital, Cape Town, South Africa

5. MRC Unit on Child & Adolescent Health, University of Cape Town, Cape Town, South Africa

6. Division of Clinical Pharmacology, Department of Medicine, University of Cape Town, Cape Town, South Africa

Abstract

Ethionamide has proven efficacy against both drug-susceptible and some drug-resistant strains of Mycobacterium tuberculosis . Limited information on its pharmacokinetics in children is available, and current doses are extrapolated from weight-based adult doses. Pediatric doses based on more robust evidence are expected to improve antituberculosis treatment, especially in small children.

Funder

National Research Foundation

South African Medical Research Council

HHS | NIH | Eunice Kennedy Shriver National Institute of Child Health and Human Development

Wellcome Trust

Swedish Foundation for International Cooperation in Research and Higher Education

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology

Link

https://journals.asm.org/doi/pdf/10.1128/AAC.01984-19

Reference54 articles.

1. Incidence of multidrug-resistant tuberculosis disease in children: systematic review and global estimates

2. A review of the use of ethionamide and prothionamide in childhood tuberculosis

3. World Health Organization. 2016. WHO guidelines for the programmatic management of drug resistant tuberculosis: 2016 update. World Health Organization, Geneva, Switzerland.

4. Cerebrospinal fluid concentrations of ethionamide in children with tuberculous meningitis

5. ETHIONAMIDE: ITS PASSAGE INTO THE CEREBROSPINAL FLUID IN MAN

Cited by 8 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. Perinatal tuberculosis—An approach to an under-recognized diagnosis;Frontiers in Public Health;2023-11-07

2. A model-based approach for a practical dosing strategy for the short, intensive treatment regimen for paediatric tuberculous meningitis;Frontiers in Pharmacology;2023-04-25

3. Prothionamide Dose Optimization Using Population Pharmacokinetics for Multidrug-Resistant Tuberculosis Patients;Antimicrobial Agents and Chemotherapy;2022-09-20

4. Integration of advanced methods and models to study drug absorption and related processes: An UNGAP perspective.;European Journal of Pharmaceutical Sciences;2021-12

5. Effect of Isoniazid Intake on Ethionamide Pharmacokinetics and Target Attainment in Multidrug-Resistant Tuberculosis Patients;Antimicrobial Agents and Chemotherapy;2021-09-17