High prevalence of OXA-23 carbapenemase-producing Proteus mirabilis among amoxicillin-clavulanate resistant isolates in France-Reference-Cited by-同舟云学术

High prevalence of OXA-23 carbapenemase-producing Proteus mirabilis among amoxicillin-clavulanate resistant isolates in France

Published:2021-12-20 Issue: Volume: Page:
ISSN:0066-4804
Container-title:Antimicrobial Agents and Chemotherapy
language:en
Short-container-title:Antimicrob Agents Chemother

Author:

Lombes Amélie¹²,Bonnin Rémy A.²³,Laurent Frédéric⁴,Guet-Revillet Hélène⁵,Bille Emmanuelle⁶,Cattoir Vincent⁷^ORCID,Fangous Marie-Sarah⁸^ORCID,Le Brun Cécile⁹,Fihman Vincent¹⁰,Janvier Frédéric¹¹,Otto Marie-Pierre¹¹,Potron Anais¹²^ORCID,Corvec Stéphane¹³^ORCID,Ruffier D'epenoux Louise¹³,Mizrahi Assaf¹⁴¹⁵,Laurent Dortet¹²³

Affiliation:

1. CHU de Bicêtre, Laboratoire de Bactériologie-Hygiène, Assistance Publique des Hôpitaux de Paris, Le Kremlin-Bicêtre, France

2. INSERM UMR 1184, Team RESIST, Faculté de Médecine, Université Paris-Saclay, Le Kremlin-Bicêtre, France

3. Centre National de Référence de la Résistance aux Antibiotiques, Le Kremlin-Bicêtre, France

4. Hospices Civils de Lyon, Department de Bactériologie, Institut des Agents infectieux, Lyon, France

5. Hôpital Purpan, Laboratoire de Bactériologie-Hygiène, Toulouse, France

6. CHU Necker-Enfants Malades, Laboratoire de Microbiologie, Assistance Publique des Hôpitaux de Paris, Paris, France

7. CHU de Rennes, Service de Bactériologie-Hygiène Hospitalière, F-35033 Rennes, France

8. Centre Hospitalier de Cornouaille, Laboratoire de biologie médicale, Quimper, France

9. CHRU de Tours, Hôpital Bretonneau, Service de Bactériologie-Virologie-Hygiène, Tours, France

10. CHU Henri Mondor, Service de Bactériologie-Virologie-Hygiène, Créteil, France

11. Hôpital d'Instruction des Armées Sainte-Anne, Service de microbiologie et hygiène hospitalière, Toulon, France

12. Centre National de Référence de la Résistance aux Antibiotiques, Laboratoire de Bactériologie, CHU de Besançon, Besançon, France

13. CHU de Nantes, Service de Bactériologie et des Contrôles Microbiologiques, CRCINA U1232, Nantes, France

14. Service de Microbiologie Clinique, Groupe Hospitalier Paris Saint-Joseph, Paris, France

15. Institut Micalis UMR 1319, Université Paris-Saclay, INRAe, AgroParisTech, Châtenay Malabry, France

Abstract

In this multicentric study performed in 12 French hospitals, we reported that 26.9% (14/52) of the amoxicillin/clavulanate-resistant Proteus mirabilis isolates produced the OXA-23 carbapenemase. We found that inhibition zone diameter less than 11 mm around amoxicillin/clavulanate disc was an accurate screening cut-off to detect these OXA-23 producers. We confirmed by whole genome sequencing that these OXA-23-producers all belonged to the same lineage that has been demonstrated to disseminate OXA-23 or OXA-58 in P. mirabilis .

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology

Link

https://journals.asm.org/doi/pdf/10.1128/AAC.01983-21

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