Ethambutol Is Cleared by a Contemporary High-Flux Hemodialyzer, and Drug Monitoring Ensures Safety and Therapeutic Effect

Author:

Chew Rusheng12,Jongbloed Sarah1,Jegatheesan Dev3,Healy Helen23,Ta Kim4,Ungerer Jacobus5,McWhinney Brett5,Donovan Peter26,Woods Marion L.12

Affiliation:

1. Department of Infectious Diseases, Royal Brisbane and Women's Hospital, Brisbane, Australia

2. School of Medicine, University of Queensland, Brisbane, Australia

3. Department of Renal Medicine, Royal Brisbane and Women's Hospital, Brisbane, Australia

4. Department of Pharmacy, Royal Brisbane and Women's Hospital, Brisbane, Australia

5. Department of Chemical Pathology, Pathology Queensland, Brisbane, Australia

6. Department of Clinical Pharmacology, Royal Brisbane and Women's Hospital, Brisbane, Australia

Abstract

ABSTRACT It is uncertain, given the lack of recent data and the inconclusive nature of previous data, whether ethambutol is cleared by hemodialysis using contemporary dialyzers. We measured serum ethambutol concentrations before, during, and 1 h after hemodialysis in a 75-year-old Caucasian man receiving ethambutol for disseminated Bacille Calmette-Guérin infection. There was a mean 41% decrease in serum ethambutol concentration during dialysis, confirming the hemodialyzability of ethambutol and the utility of drug monitoring in ensuring safety.

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology

Reference20 articles.

1. Korman TM . 2010. Ethambutol, p 1570–1579. InGraysonMLCroweSMMcCarthyJSMillsJMoutonJWNorrbySR (ed), Kucers' the use of antibiotics,6th ed: a clinical review of antibacterial, antifungal and antiviral drugs. CRC Press,Boca Raton, FL.

2. Ethambutol

3. World Health Organization. 2006. Ethambutol efficacy and toxicity: literature review and recommendations for daily and intermittent dosage in children. World Health Organization,Geneva, Switzerland.

4. Anti-tuberculosis drug susceptibility testing of Mycobacterium bovis BCG Tokyo strain;Shishido Y;Int J Tuberc Lung Dis,2007

5. Susceptibility of Mycobacterium bovis BCG Vaccine Strains to Antituberculous Antibiotics

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