Ethambutol Is Cleared by a Contemporary High-Flux Hemodialyzer, and Drug Monitoring Ensures Safety and Therapeutic Effect-Reference-Cited by-同舟云学术

Ethambutol Is Cleared by a Contemporary High-Flux Hemodialyzer, and Drug Monitoring Ensures Safety and Therapeutic Effect

Published:2017-06 Issue:6 Volume:61 Page:
ISSN:0066-4804
Container-title:Antimicrobial Agents and Chemotherapy
language:en
Short-container-title:Antimicrob Agents Chemother

Author:

Chew Rusheng¹²,Jongbloed Sarah¹,Jegatheesan Dev³,Healy Helen²³,Ta Kim⁴,Ungerer Jacobus⁵,McWhinney Brett⁵,Donovan Peter²⁶,Woods Marion L.¹²

Affiliation:

1. Department of Infectious Diseases, Royal Brisbane and Women's Hospital, Brisbane, Australia

2. School of Medicine, University of Queensland, Brisbane, Australia

3. Department of Renal Medicine, Royal Brisbane and Women's Hospital, Brisbane, Australia

4. Department of Pharmacy, Royal Brisbane and Women's Hospital, Brisbane, Australia

5. Department of Chemical Pathology, Pathology Queensland, Brisbane, Australia

6. Department of Clinical Pharmacology, Royal Brisbane and Women's Hospital, Brisbane, Australia

Abstract

ABSTRACT It is uncertain, given the lack of recent data and the inconclusive nature of previous data, whether ethambutol is cleared by hemodialysis using contemporary dialyzers. We measured serum ethambutol concentrations before, during, and 1 h after hemodialysis in a 75-year-old Caucasian man receiving ethambutol for disseminated Bacille Calmette-Guérin infection. There was a mean 41% decrease in serum ethambutol concentration during dialysis, confirming the hemodialyzability of ethambutol and the utility of drug monitoring in ensuring safety.

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology

Link

https://journals.asm.org/doi/pdf/10.1128/AAC.01988-16

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