Bacille Calmette-Guérin Vaccine–Induced Tuberculous Elbow Osteomyelitis in an Infant

Author:

Ishibashi Shigeki1ORCID,Kodama Akira1ORCID,Maruyama Natsuki2,Tanaka Teruyasu1ORCID,Hayashi Yuta3,Shinomiya Rikuo3ORCID,Okada Satoshi2ORCID,Adachi Nobuo1

Affiliation:

1. Department of Orthopaedic Surgery, Graduate School of Biomedical and Health Sciences, Hiroshima University Kasumi, Hiroshima, Japan

2. Department of Pediatrics, Hiroshima University Graduate School of Biomedical and Health Sciences, Kasumi, Hiroshima, Japan

3. Department of Musculoskeletal Traumatology and Reconstructive Surgery, Graduate School of Biomedical and Health Sciences, Hiroshima University Kasumi, Hiroshima, Japan

Abstract

Case: We report a case of Bacillus Calmette-Guérin (BCG) vaccine–induced osteomyelitis of the distal end of the right humerus in a 1-year and 8-month–old girl. The patient was treated with debridement and a 12-month antituberculosis drug. After 3 years of follow-up, no growth disturbances or sequelae were observed. Conclusion: BCG osteomyelitis is difficult to diagnose because of its rarity. It is important to suspect BCG osteomyelitis based on symptoms and blood tests and to perform PCR testing. Long-term follow-up after treatment is necessary to monitor for recurrence and avoid growth disturbances until epiphyseal line closure occurs.

Publisher

Ovid Technologies (Wolters Kluwer Health)

Subject

Orthopedics and Sports Medicine,Surgery

Reference17 articles.

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3. Management of Bacillus Calmette-Guérin osteomyelitis/osteitis in immunocompetent children-a systematic review;Lin;Vaccine.,2015

4. Clinical manifestations, management, and outcomes of osteitis/osteomyelitis caused by Mycobacterium bovis Bacillus Calmette-Guérin in children: comparison by site(s) of affected bones;Huang;J Pediatr.,2019

5. Osteitis caused by Bacille Calmette-Guérin vaccination: a retrospective analysis of 222 case;Kröger;J Infect Dis.,1995

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