Unlocking the Healing Potential

Author:

Shahzad Hania1ORCID,Lee Maximillian1ORCID,Munjal Vikas1ORCID,Veliky Cole1ORCID,Yu Elizabeth1ORCID

Affiliation:

1. Department of Orthopaedics, The Ohio State University Wexner Medical Center, Columbus, Ohio

Abstract

» Cannabinoids, such as D9-tetrahydrocannabinol and cannabidiol, interact with endocannabinoid receptors in the central nervous system and immune system, potentially offering pain relief. The entourage effect, resulting from the interaction of multiple cannabis components, may enhance therapeutic impact and efficacy, making them promising candidates for exploring pain relief in spine operations, known to be among the most painful operative procedures.» The use of cannabinoids in pain management requires careful consideration of safety, including their cognitive and psychomotor effects, potential cardiovascular risks, risk of dependence, mental health implications, and drug interactions.» Few studies have analyzed cannabinoid use in relation to spine surgery, with variable results reported, indicating possible effects on reoperation rates, mortality, complications, postoperative opioid use, and length of hospital stay.» Current knowledge gaps exist in the understanding of cannabinoid effects on spine surgery, including the exploration of different administration routes, timing, dosage, and specific outcomes. In addition, mechanistic explanations for the observed results are lacking.» Ethical considerations related to informed consent, medical expertise, societal impact, and legal compliance must also be thoroughly addressed when considering the utilization of cannabinoids in spinal pathologies and back pain treatment.

Publisher

Ovid Technologies (Wolters Kluwer Health)

Subject

Orthopedics and Sports Medicine,Surgery

Reference73 articles.

1. Medicinal cannabis: history, pharmacology, and implications for the acute care setting;Bridgeman;Pharm Ther,2017

2. The pharmacokinetics and efficacy of ropivacaine continuous wound instillation after spine fusion surgery;Bianconi;Anesth Analg,2004

3. Pain intensity on the first day after surgery: a prospective cohort study comparing 179 surgical procedures;Gerbershagen;Anesthesiology,2013

4. Triaging spine surgery in the COVID-19 era;Donnally;Clin Spine Surg,2020

5. Surgery for low back pain: a review of the evidence for an American Pain Society clinical practice guideline;Chou;Spine (Phial Pa 1976),2009

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