Voltammetric folic acid sensor based on nickel ferrite nanoparticles modified-screen printed graphite electrode

Abstract

In this study, an electrochemical sensor for the quantification of folic acid with voltam­metric detection in physiological conditions was constructed. For this purpose, nickel ferrite (NiFe2O4) nanoparticles were used to modify the surface of a screen-printed graphite electrode (NiFe2O4/SPGE) and applied in the determination of folic acid. The modified electrode displays a strong electrochemical response to folic acid. Folic acid was determined electrochemically using the differential pulse voltammetry (DPV) technique with a detection limit of 0.09±0.001 µM in 0.2–147.0 µM linear range in phosphate buffer solution (PBS) at pH 7.0 with this NiFe2O4/SPGE sensor, which has the best electron transfer rate. Also, the sensitivity of the modified electrode was obtained as 0.1139 µA µM-1. The NiFe2O4/SPGE sensor was successfully applied for the determination of folic acid in real samples.