Use of Short Oral Regimens for Treatment of Drug Resistant Tuberculosis in a Patient with HIV Infection

Author:

Degtyareva S. Yu.1ORCID,Kuznetsova T. A.2,Zimina V. N.3ORCID

Affiliation:

1. RUDN University

2. Vladimir Regional Center for Specialized Phthisiopulmonary Care

3. RUDN University; National Medical Research Center of Phthisiopulmonology and Infectious Diseases

Abstract

We present the clinical case of effective treatment of tuberculosis in a patient with disseminated pulmonary and extrapulmonary pre-extensive drug resistant tuberculosis, HIV-infection and other severe opportunistic and concomitant infections. Short all-oral regimen has been used for the treatment. This clinical case demonstrates the clinical efficacy of modern treatment regimens, good compatibility with other drugs and management of adverse events without treatment interruption.

Publisher

LLC "Medical Knowledge and Technologies"

Subject

General Medicine

Reference13 articles.

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2. Federalnye klinicheskiye rekomendatsii po diagnostike i lecheniyu tuberkuleza organov dykhaniya s mnozhestvennoy i shirokoy lekarstennoy ustoichivostyu vozbuditelya. [Federal guidelines for diagnosis and treatment of respiratory tuberculosis with multiple and extensive drug resistance]. Rossiyskoe Obschestvo Ftiziatrov Publ., 72 p.

3. Filinyuk O.V., Schegertsov D.Yu., Kabanets N.N., Amichba D.E. Tolerability and Efficacy of Chemotherapy Containing Bedaquiline in Patients with Multiple Drug Resistant Pulmonary Tuberculosis. Tuberculosis and Lung Diseases, 2022, vol. 100 no. 9, pp. 40-45. (In Russ.) https://doi.org/10.21292/2075-1230-2022-100-9-40-45

4. Common Terminology Criteria for Adverse Events (CTCAE) Version 5.0; 2017. P. 155. Available from: https://ctep.cancer.gov/protocoldevelopment/electronic_applications/ctc.htm.

5. Global tuberculosis report 2017. Geneva: World Health Organization; 2017. P. 262. URL: https://reliefweb.int/sites/reliefweb.int/files/resources/9789241565516-eng.pdf.

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