Affiliation:
1. National Medical Research Center of Phthisiopulmonology and Infectious Diseases, Russian Ministry of Health
2. Russian Medical Academy of On-going Professional Education, Russian Ministry of Health
Abstract
The objective: to study the conditions of implementation of short-course (4 and 9 months) treatment regimens in tuberculosis patients and simulate their impact on the frequency of early treatment interruption (ETI) by patients.Subjects and Methods. Data on the treatment duration from enrollment to chemotherapy interruption in 8,029 tuberculosis patients were studied. Data were obtained from the Federal Register of Tuberculosis Cases for 2020. Of these, 3,379 patients were treated with regimens for susceptible or suspected susceptible tuberculous mycobacteria excluding isoniazid resistant tuberculosis, and 4,650 patients received regimens for rifampicin-resistant tuberculous mycobacteria.Results. The median duration of treatment from onset to ETI was 124 (95% CI 120-128) days in 3,379 patients, 224 (95% CI 215-233) days in 4,650 patients, or 170 (95% CI 157-181) days if there was a history of treatment interruption. Simulation of ETI terms when short-course chemotherapy regimens were introduced has shown that we can expect a 2-fold decrease in the proportion of patients who interrupted chemotherapy among patients with preserved/suspected susceptibility of tuberculous mycobacteria, and 1.3-1.7-fold decrease among patients with confirmed/presumed drug resistance of tuberculous mycobacteria at least to rifampicin.
Publisher
LLC "Medical Knowledge and Technologies"
Reference11 articles.
1. Baryery v dostupe k lecheniyu tuberkuleza glazami patsiyentov, zhivushchikh s VICH-infektsiyey i tuberkulezom v Rossii. [Barriers to accessing treatment of tuberculosis from the point of view of HIV-infected patients in Russia]. Available: https://evanetwork.ru/wp-content/uploads/2015/06/Bareryi-v-dostupe-k-lecheniyu-tu berkul eza-glazami-patsientov-zhivushhih-s-VICH_1.pdf. Accessed: 18.07.2023 г.
2. Vasilyeva I.A., Sterlikov S.A., Testov V.V., Mikhaylova Yu.V., Obukhova O.V., Ponomarev S.B., Kudlay D.A. Otraslevye i ekonomicheskiye pokazateli protivotuberkulyoznoy raboty v 2019-2020 gg. Statisticheskiye materialy. [Sectoral and economic rates of tuberculosis control in 2019-2020. Statistic materials]. Moscow, FGBU NMITS FPI Minzdrava Rossii Publ., 2022, 64 p.
3. Maryandyshev A.O., Kulizhskaya A.I., Khimova E.S., Perkhin D.V., Sveshnikova O.M., Presnova S.E., Kurochkina N.P., Sotnikov A.S., Lesheva N.A., Vasilyeva I.A. Short course treatment regimens for multiple drug resistant tuberculosis in Arkhangelsk, Murmansk and Belgorod Regions. Tuberculosis and Lung Diseases, 2019, vol. 97, no. 7, pp. 5-10. (In Russ.) https://doi.org/10.21292/2075-1230-2019-97-7-5-10.
4. Ungureanu T.N., Grzhibovskiy A.M. Comparison of three or more independent groups using the nonparametric Kraskell-Wallis criterion in the STATA program. Ekologiya Cheloveka, 2014, no. 6, pp. 55-58. (In Russ.)
5. Shurygin A.A., Makarova E.A. The effect of early treatment interruption on treatment efficacy. Mediko-Farmatsevticheskiy Journal Puls, 2021, vol. 23, no. 9, pp. 136-141. (In Russ.)