Affiliation:
1. St. Petersburg Research Institute of Phthisiopulmonology, Russian Ministry of Health;
St. Petersburg University
2. St. Petersburg Research Institute of Phthisiopulmonology, Russian Ministry of Health
Abstract
The objective: to assess changes in the data on drug resistance of M. tuberculosis for 2015-2021 and compare it with data for 2012-2014.Subjects and Methods. Using continuous sampling, the frequency of drug resistance of Mycobacterium tuberculosis (MTB DR) was studied in isolates from 151 pulmonary tuberculosis (PTB) patients and isolates from 805 extrapulmonary tuberculosis (EPTB) patients, who were treated at the clinic of St. Petersburg Research Institute of Phthisiopulmonology in 2015-2021. The results were compared with similar data for 2012-2014 which was published in 2016.Results. In 2015-2021 versus 2012-2014, the overall frequency of MTB DR decreased by 4.2% in pulmonary tuberculosis patients (from 90.1 to 85.9%) and by 2.9% in extrapulmonary tuberculosis patients (from 80.2 to 77.4%). The structure of MTB DR in pulmonary tuberculosis changed insignificantly, the frequency of MDR decreased from 42.5 to 36.5%, and XDR (as per the definitions before 2022) remained the same – 39.5%. In extrapulmonary tuberculosis, the structure of MTB DR deteriorated due to lower frequency of MDR (from 66.3 to 48.3%) and higher frequency of XDR (from 3.2 to 19.0%, p<0.01).
Publisher
LLC "Medical Knowledge and Technologies"
Reference12 articles.
1. Galkin V.B., Sterlikov S.A., Yablonskiy P.K. Tuberculosis burden in the Russian Federation. Part 2. Changes in the prevalence of multiple drug resistant tuberculosis. Meditsinsky Alyans, 2022, vol. 10, no. 4, pp. 6-18. (In Russ.) https://doi.org/10.36422/23076348-2022-10-4-6-18
2. Litvinov V.I., Nosova E.Yu. The problem of drug resistance of M. tuberculosis. Tuberkulez i Sotsialno-Znachimye Zabolevaniya, 2021, no. 2, pp. 70-82. (In Russ.)
3. Naumov A.G., Pavlunin A.V. Mechanisms of development of medicine stability Mycobacterium tuberculosis: is there a chance to win? Pulmonologiya, 2021, vol. 31, no. 1, pp. 100-108. (In Russ.) https://doi.org/10.18093/0869-0189-2021-31-1-100-108
4. Edict no. 109 by RF MoH as of 21.03.2003 On Improvement of TB Control Measures in the Russian Federation. (In Russ.) Available: http://docs.cntd.ru/document/901868614 Accessed April 12, 2023
5. Tuberkulez u vzroslykh. Klinicheskie rekomendatsii KR-16. [Tuberculosis in adults. Guidelines. G-16]. Moscow, 2022.