100 Years of Vaccination against Tuberculosis – Lessons Learnt and Prospects

Author:

Bogorodskaya E. M.1ORCID,Kudlay D. A.2ORCID,Slogotskaya L. V.1ORCID

Affiliation:

1. Moscow Research and Clinical Center for Tuberculosis Control of the Moscow Government Department of Health; Russian Medical Academy of On-going Professional Education, Russian Ministry of Health

2. I.M. Sechenov First Moscow State Medical University (Sechenov University), Russian Ministry of Health; Lomonosov Moscow State University; Immunology Research Institute by the Russian Federal Medical Biological Agency

Abstract

The article presents a literature review dedicated to the 100th anniversary of introduction of the BCG vaccine against tuberculosis; it analyzes of 83 publications by Russian and foreign authors. The results of the BCG vaccination used in various clinical studies and real clinical practice are assessed. The article presents data on development of new candidate vaccines and mechanisms of their effect on various parts of the immune system. Candidate vaccines are of particular interest, these candidate vaccines are used not only for prevention before infants are exposed to the infection for the first time, but also for therapy, the vaccines are aimed at therapeutic action against tuberculosis and latent tuberculosis infection.

Publisher

LLC "Medical Knowledge and Technologies"

Reference83 articles.

1. Averbakh A.A., Litvinov V.I. Immunologicheskie osnovy protivotuberkuleznoy vaktsinatsii. [Immunological basics of anti-tuberculosis vaccination]. Moscow, Meditsina Publ., 1970, 222 p.

2. Weisfeller Yu.K. The mechanism of immunity and allergies in case of tuberculosis. Problemy Tuberkuleza, 1946, no. 2, pp. 3-15. (In Russ.)

3. Lyubarsky V.A. On the issue of anti-tuberculosis vaccination. Voprosy Tuberkuleza, 1926, vol. 4, no. 3, pp. 14-15. (In Russ.)

4. Togunova A.I., Zhulina L.V., Khatenever M.L. About antigens and crude extracts of Mycobacterium tuberculosis. Problemy Tuberkuleza, 1962, no. 4, pp. 71-76. (In Russ.)

5. Togunova A.I. On the biology of the BCG strain. Borba s Tuberkulezom, 1932, no. 7, pp. 591-599. (In Russ.)

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