Iron metabolIsm and ferroptosIs as a therapeutIc target

Abstract

The cell death is the most important characteristic of any tissue, including malignant tumors. It controls the proliferation and metastasis. Besides cell death determines the development of the drug resistance. In this context, the understanding of the mechanisms and searching for the targets of the alternative cellular loss can be a promising therapeutic strategy for long-term control of the tumor growth. This paper describes the mechanisms of ferroptosis, an iron-mediated non-apoptotic cell death due to lipid peroxidation. In this regard, in addition to the emergence of new therapeutic options that can affect key aspects of this process, the search for predictive markers of such metabolic therapy is also important for the clinicians.