Identification of Cancer-specific Constituent Elements inside Super-enhancers (cSEAdb) v1-Reference-Cited by-同舟云学术

Identification of Cancer-specific Constituent Elements inside Super-enhancers (cSEAdb) v1

Published:2024-01-03 Issue: Volume: Page:
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Author:

Liu Xiang

Abstract

Super enhancers (SE) are large genomic elements composed of multiple constituent enhancers. As super enhancers are key regulators associated to cancer mechanisms, identifying cancer-specific super enhancer signatures improves our understanding of cancer-associated gene regulation. This protocol aims to provide a computational framework to identify cancer-specific super enhancer signatures at their constituent levels, using public H3L27Ac ChIP-seq data of the NCI-60 cancer cell panel. The protocol covers from data acquisition, pre-processing, statistical modeling and cancer-specific signature identification. It also provides links of scripts toward building an R data object for the storage, management and query of these signatures.

Publisher

ZappyLab, Inc.

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