Affiliation:
1. Altai State Medical University, Ministry of Health of Russia; Altai Branch of the National Medical Research Center of Hematology, Ministry of Health of Russia
2. Altai State Medical University, Ministry of Health of Russia
3. Regional Clinical Hospital
Abstract
Aim of the study – to establish the features of inheritance of the F5L:G(1961)A and F2:G(20210)A genotypes and to assess their influence on the course and outcomes of pregnancy.Materials and methods. The object of the study was 70 mother–child pairs: 50 women, carriers of the F5L:G(1961)A mutation, and their children; 20 female patients, carriers of the F2:G(20210)A mutation, their children. Additionally, 18 families of women, carriers of the factor V Leiden mutation, in three generations were studied.Results. Carriage of the F5:(1961)GA and F2:(20210)GA genotypes in fetuses is associated with the risk of developing gestational complications in their mothers, which are primarily realized when the maternal laboratory phenotype is manifested. A higher frequency of occurrence of the minor allele A20210 of the FII gene was determined in children than in the older generation (p = 0,0006).
Subject
Oncology,Hematology,Pediatrics, Perinatology and Child Health
Reference18 articles.
1. Nowak-Gottl U., Kurnik K., Krumpel A., Stoll M. Thrombophilia in the young. Haemostaseologie 2008;28(1–2):16–20. doi: 10.1055/s-0037-1616930.
2. Momot A.P. Problema trombofilii v klinicheskoi praktike. Rossiiskii zhurnal detskoi gematologii i onkologii 2015;1:36–48. doi: 10.17650/2311-1267-2015-1-36-48. [Momot A.P. The problem of thrombophilia in clinical practice. Rossiyskiy zhurnal detskoy gematologii i onkologii = Russian Journal of Pediatric Hematology and Oncology 2015;1:36–48. (In Russ.)].
3. Rodger M.A., Walker M.C., Smith G.N., Wells P.S., Ramsay T., Langlois N.J., Carson N., Carrier M., Rennicks White R., Shachkina S., Wen S.W. Is thrombophilia associated with placenta-mediated pregnancy complications? A prospective cohort study. J Thromb Haemost 2014;12(4):469–78. doi: 10.1111/jth.13017.
4. Shi X., Xie X., Jia Y., Li S. Maternal genetic polymorphisms and unexplained recurrent miscarriage: a systematic review and metaanalysis. Clin Genet 2017;91(2):265–84. doi: 10.1111/cge.12910.
5. Kamali M., Hantoushzadeh S., Borna S., Neamatzadeh H., Mazaheri M., Noori-Shadkam M., Haghighi F. Association between Thrombophilic Genes Polymorphisms and Recurrent Pregnancy Loss Susceptibility in the Iranian Population: a Systematic Review and Meta-Analysis. Iran Biomed J 2018;22(2):78–89. doi: 10.22034/ibj.22.2.78.