The use of proton radiation therapy in a patient with melanotic neuroectodermal tumor of infants of the anterior fontanel: description of a clinical case

Author:

Faseeva N. D.1ORCID,Martynova N. I.1ORCID,Maksimov M. D.1ORCID,Boyko K. F.1ORCID,Vorobyev N. A.2ORCID,Berezina N. A.1ORCID,Plakhotina N. A.1ORCID,Reshchikov D. A.3ORCID,Vasiliev I. G.3ORCID,Mai R. B.3ORCID,Titova M. A.4ORCID,Zheludkova O. G.5ORCID

Affiliation:

1. DTC IIBS named after S. Berezin

2. DTC IIBS named after S. Berezin; Saint-Petersburg State University; North-Western State Medical University named after I.I. Mechnikov, Ministry of Health of Russia

3. Russian Children’s Clinical Hospital of the N.I. Pirogov Russian National Research Medical University, Ministry of Health of Russia

4. Saint-Petersburg State Pediatric Medical University, Ministry of Health of Russia

5. DTC IIBS named after S. Berezin; Scientific and Practical Center for Specialized Medical Care for Children named after V.F. Voyno-Yasenetsky Moscow Healthcare Department

Abstract

Melanotic neuroectodermal tumor (MNET) of infants is a rare benign neoplasm detected mainly in children of the first year of life. Standard therapy consists of radical surgical removal of the tumor. Currently, the treatment of patients with recurrent and unresectable forms of the disease is relevant. The number of publications using polychemotherapy and radiation therapy is extremely limited. This article describes a clinical case of the occurrence of MNET in the anterior fontanel with a recurrent course. Proton radiation therapy was chosen as an alternative treatment method.

Publisher

OOO Grafika

Subject

Oncology,Hematology,Pediatrics, Perinatology and Child Health

Reference13 articles.

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5. Suleymanova A.M., Ozerov S.S., Roshchin V.Yu., Grachev N.S., Bolshakov N.A., Druy A.E., Tereshchenko G.V., Konovalov D.M., Sagoyan G.B., Shamanskaya T.V., Kachanov D.Yu., Varfolomeeva S.R. Melanotic neuroectodermal tumor of infancy: a description of the experience of Dmitry Rogachev National Medical Research Center of Pediatric Hematology, Oncology and Immunology and literature review. Rossiyskiy zhurnal detskoy gematologii i onkologii. = Russian Journal of Pediatric Hematology and Oncology. 2019;6(3):44–53. (In Russ.).

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