Affiliation:
1. N.N. Blokhin National Medical Research Centre of Oncology, Ministry of Health of Russia
2. N.N. Blokhin National Medical Research Centre of Oncology, Ministry of Health of Russia;
Russian Medical Academy of Continuous Professional Education, Ministry of Health of Russia
Abstract
Malignant neoplasms (MNP) of the gastrointestinal tract in children are extremely rare and account for 1.2 % of all MNP. According to world literature, the incidence of gastric cancer is no more than 0.05 % of all cases of MNP of the gastrointestinal tract in children. In national and foreign literature, only isolated cases of stomach cancer in children and adolescents aged 10 to 18 years are described. Clinical manifestations of the disease, as in patients over the age of 18, are non-specific – epigastric pain, loss of appetite, weight loss, ascites, anemia, melena and others. In this regard, the diagnosis occurs at the late stages of the disease and, therefore, is characterized by an unfavorable prognosis. Gastric signet ring cell carcinoma (SRCC) is an uncommon histologic subtype of adenocarcinoma and usually occurs in people aged 20 to 40 years. We would like to report an extremely rare case of SRCC in a 14-year-old child.
Subject
Oncology,Hematology,Pediatrics, Perinatology and Child Health
Reference35 articles.
1. Brecht I.B., Graf N., Schweinitz D.V., Fruhwald M.C., Bielack S.S., Schneider D.T. Networking for children and adolescents with very rare tumors: foundation of the GROH pediatric rare tumor group. Klinische Padiatrie. 2009;221(3):181–5. doi: 10.1155/2014/527471.
2. Zhang W., Liang W.Q., Cai A.Z., Wang P.P., Xi H.Q., Liu G.X., Wei B. Clinicopathological characteristics of gastric cancer in adolescents aged 10–24 years: 17-year experience of 17 years in a single institute. Zhonghua Wei Chang Wai Ke Za Zhi. 2020;23(10):963–8. doi: 10.3760/cma.j.cn.441530-20190918-00351.
3. Al-Hussaini А., AlGhamdi S., Alsaaran R., Al-Kasim F., Habib Z., Ourfali N. Gastric adenocarcinoma presenting with gastric outlet obstruction in a child. Case Rep Gastrointest Med. 2014;2014:527471. doi: 10.1155/2014/527471.
4. Сhang V.Y., Federman N., Martinez-Agosto J., Tatishchev S.F., Nelson S.F. Whole exome sequencing of pediatric gastric adenocarcinoma reveals an atypical presentation of Li-Fraumeni syndrome. Pediatr Blood Cancer. 2013;60:570–4. doi: 10.1002/pbc.24316.
5. Lee Y.T., Ng E.K., Hung L.C., Chung S.C., Ching J.Y., Chan W.Y., Chu W.C., Sung J.J. Accuracy of endoscopic ultrasonography in diagnosing ascites and predicting peritoneal metastases in gastric cancer patients. Gut. 2005;54:1541–5. doi: 10.1136/gut.2004.055772.