Synthesis of Aromatic Schiff Bases and Co(II), Ni(II) and Cu(II) Complexes: Investigation of Antımicrobial Activities

Abstract

Two types of Schiff base ligands were synthesized with the reaction of N,N-diethyl-p-phenylenediamine and salicylaldehyde , 2,4-dihydroxybenzaldehyde separately. Co(II), Cu(II), Ni(II) complexes of the obtained ligants were synthesized and characterized using FT-IR, UV.-Vis., ICP-OES, TG/DTA/DTG, 1H and 13C NMR) and elemental analyses (C, H, N and metal contents analyses). The ligands and metal complexes obtained in the study were gram positive; Staphylococcus aureus Rosenbach ATCC-6538, Bacillus cereus ATCC 7064, gram negative; Escherichia coli ATCC-8739, Salmonella typhimurium and Candida albicans ATCC-90028 yeast strain biological activities against were investigated. It was determined that the L1 ligand and its complexes showed 8.15-12.99 mm diameter inhibition zones against microorganisms, and the L2 and complexes showed 7.66-13.88 mm diameter inhibition zones against microorganisms. Since these complex structures have positive effects against gram-negative and gram-positive strains, it is possible to be an alternative to antibiotics that are used extensively in our lives.