Analysis in the generation of reactive oxygen species through the interaction between the secondary radiation of the compound system (cisplatin and silica nanoparticle) and intracellular water

Abstract

Through computer simulations of Monte Carlo (TOPAS-nBio code), the generation of reactive oxygen species will be analyzed when applying external radiation with electrons which energy is 3 and 5 keV to physical system: composite system and intracellular water. This study of the generation of reactive species was focused exclusively on the interaction between secondary radiation from the composite system and intracellular water.This secondary radiation originates from the platinum atom and oxygens (from the composite system) the influence being greater relative to platinum; which mainly consists of electrons called Auger. In this work, only the influence of these ionizing electrons in intracellular water is considered, leading to the generation of reactive oxygen species. Furthermore, the interaction between the nanoparticle surface and cisplatin was not taken into account.