Genetic Susceptibility in Dupuytren’s Disease: Lack of Association of a Novel Transforming Growth Factor β2Polymorphism in Dupuytren’s Disease-Reference-Cited by-同舟云学术

Genetic Susceptibility in Dupuytren’s Disease: Lack of Association of a Novel Transforming Growth Factor β2Polymorphism in Dupuytren’s Disease

Published:2002-02 Issue:1 Volume:27 Page:47-49
ISSN:0266-7681
Container-title:Journal of Hand Surgery
language:en
Short-container-title:Journal of Hand Surgery

Author:

BAYAT A.¹,ALANSAR A.¹,HAJEER A. H.¹,SHAH M.¹,WATSON J. S.¹,STANLEY J. K.¹,FERGUSON M. W. J.¹,OLLIER W. E. R.¹

Affiliation:

1. From the Hand Surgery Units, Wrightington Hospital, Wigan & Withington Hospital, Manchester and the ARC-Epidemiology Unit in collaboration with the Division of Cells, Immunology and Development, School of Biological Sciences, University of Manchester, Manchester, UK

Abstract

The genes involved in the pathogenesis of Dupuytren’s disease have yet to be identified. In this study, we tested for an association between Dupuytren’s disease (DD) and a novel insertion polymorphism within the 5′-untranslated region (5′-UTR), of the TGFβ2gene. DNA samples from 179 DD patients and 187 ethnically matched controls were examined. There was no statistically significant difference in TGFβ2allele frequency distributions between cases and controls for the TGFβ2polymorphism.

Publisher

SAGE Publications

Subject

Transplantation,Surgery

Link

http://journals.sagepub.com/doi/pdf/10.1054/JHSB.2001.0689

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